Conventional therapy for childhood acute lymphoblastic leukemia (ALL) includes prednisone and oral 6-mercaptopurine. Prior observations suggested potential advantages for dexamethasone over prednisone and for intravenous (IV) over oral 6-mercaptopurine, which remain to be validated. We report the results of a randomized trial of more than 1000 subjects that examined the efficacy of dexamethasone and IV 6-mercaptopurine. Children with National Cancer Institute standard-risk ALL were randomly assigned in a 2 × 2 factorial design to receive dexamethasone (6 mg/m/d). The second randomized assignment was for daily oral or weekly IV 6-mercaptopurine during consolidation. During maintenance, 5 days of the randomized steroid was given monthly, at the same dose, and all patients received daily oral 6-mercaptopurine. During delayed intensification, all patients received a dexamethasone dosage of 10 mg/m/d for 21 days, with taper. The NICE British National Formulary (BNF) and British National Formulary for Children (BNFc) sites are only available to users in the UK, Crown Dependencies and British Overseas Territories. If you believe you are seeing this page in error please contact us. Amoxicillin price in india Propecia beard growth Amoxicillin generic name Doxycycline acne The steroid conversion calculator can be utilized for drugs administered orally or by IV and the following. prednisone and dexamethasone on human pituitary. Table 1. Corticosteroid Dose Equivalents Equivalent Dose Steroid 1. Abimbola Farinde, PharmD, PhD Faculty, Columbia Southern University Abimbola Farinde, PharmD, PhD is a member of the following medical societies American College of Clinical Pharmacy, American Academy of HIV Medicine, American Pharmacists Association, Academy of Managed Care Pharmacy Dexamethasone is a corticosteroid that prevents the release of substances in the body that cause inflammation. Dexamethasone is used to treat many different inflammatory conditions such as allergic disorders and skin conditions. Fludrocortisone (Florinef) is used for its mineralocorticoid activity (causing increased reabsorption of sodium and loss of potassium/hydrogen). Although fludrocortisone technically possesses a small degree of anti-inflammatory activity (1/10th that of hydrocortisone), this effect is negibile at normal therapeutic doses of fludrocortisone (such as 0.05 to 0.2 mg per day). For this reason, fludrocortisone cannot realistically be converted to another corticosteroid on the basis of anti-inflammatory potency. Corticosteroids play a significant role in the treatment of acute lymphoblastic leukemia (ALL) in children. A common first line medication for acute lymphoblastic leukemia is dexamethasone because of the drug’s high potency and high anti-leukemic effects. However, due to Dexamethasone’s high potency, the drug can also produce neuropsychological side effects which could affect children’s’ cognitive development. Neuropsychological side effects can include changes in mood, decrease cognition, changes in behavior, and sleep disorders.“Steroid-induced neuropsychological side effects are important negative determinants of the quality of life of children during cancer treatment.” Replacing Dexamethasone with a less potent corticosteroid, such as prednisone, could lessen the side effects children experience. The purpose of this review was to compare the neuropsychological side effects between dexamethasone and prednisone in children treated for acute lymphoblastic leukemia. Determining if a clinically significant difference exist between dexamethasone and prednisone, could provide a more viable option with lower neuropsychological side effects for children.“The review included English-language studies of children, determined through a systematic search in the database of MEDLINE (1960 till December 2013), EMBASE (1960 till December 2013), and The Cochrane Library (till December 2013).”Articles were selected on the basis of title and abstract by two independent reviewers (LTW and MAHH) using the following inclusion criteria. Children with leukemia/ALL that were receiving dexamethasone and/or prednisone. Dexamethasone to prednisone Use of dexamethasone and prednisone in acute asthma., Corticosteroid Dose Equivalents - Medscape Reference Prescriptions from canada Dexamethasone reduces inflammation and calms down an overactive immune system and is significantly more potent than prednisolone. Long-term use can adversely affect the way the immune system reacts. more Prednisone effectively controls inflammation and an overactive immune system but may not be. Dexamethasone vs Prednisone Comparison -. Dexamethasone Uses, Dosage & Side Effects -. MedCalc Steroid Equivalence Converter. Dexamethasone long-acting. 8 mg. Methylprednisolone intermediate-acting. 8 mg. Triamcinolone intermediate-acting. 10 mg. Prednisone. Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia a. For the past 20 years, high-dose chemotherapy plus autologous stem-cell transplantation has been the standard treatment for newly diagnosed multiple myeloma in adults up to 65 years of age. 1-3.