Viagra originally developed for

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  1. mekos81 User

    Viagra originally developed for


    Some of the best inventions and discoveries in the history of civilization have been accidental. Penicillin, Teflon, radioactivity, even your favourite Coca-Cola were all chance discoveries. An accidental invention is one where scientists are trying to find a solution to problem A but chance upon a solution to problem B. This is exactly what happened in the case of mankind's dearly loved drug Viagra, that treats erectile dysfunction. In 1989, chemists at Pfizer's research centre in Kent, England, were working to find a new drug to treat hypertension and angina pectoris (chest pain due to blocked arteries). A new compound that was named Sildenafil (UK92480) was created and subsequently tested on a group of men. Unfortunately, in the clinical trials, the compound failed to have a desired effect on hypertension and did not help in dilating the muscles in the heart. In 1953 Dr Norm Larsen, founder of the Rocket Chemical Company, was trying to create a fluid which would prevent nuclear missiles from going rusty. There’s lots of waiting around in a Cold War, and the US government found that their arsenal wasn’t faring well. A group of scientists working at Pfizer's lab in Kent developed a drug called Sildenafil for the treatment of angina. Clinical trials in Swansea found that it had almost no effect on the heart or angina, but quite a pronounced side effect on another organ. Cue a quick brainstorming session by the marketing department, and Viagra soon went on sale across the globe. In 2008, the peak sales year for the drug, Pfizer sold almost $2bn worth of the stuff. The patent has now expired in much of Europe, allowing rival companies to sell their own versions.

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    Nov 30, 2017. However, young men who use Viagra as a lifestyle drug can harm their potency, because they begin to doubt their virility without it, and develop. Feb 16, 2019. A look at the history, benefits, and economics of Viagra sildenafil and. The sildenafil compound was originally developed by Pfizer for the. Sep 10, 2017. Sildenafil, the active ingredient in Viagra, was originally developed to treat cardiovascular problems. It was meant to dilate the heart's blood.

    The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Ten years ago this month, the Food and Drug Administration's approval of a little blue pill changed the sex lives of millions of men and women. Viagra, the first oral treatment for erectile dysfunction was developed accidentally by scientists at Pfizer Laboratories and was greenlighted for use by the FDA on March 27, 1998."Originally, we were testing sildenafil, the active drug in Viagra, as a cardiovascular drug and for its ability to lower blood pressure,'' Dr. Brian Klee, senior medical director at Pfizer, told French news agency, AFP. "But one thing that was found during those trials is that people didn't want to give the medication back because of the side effect of having erections that were harder, firmer and lasted longer.'' Since its approval, Viagra has been used by 35 million men around the world. It took the taboo out of impotence — former presidential candidate Bob Dole who suffered from erectile dysfunction after surgery for prostate cancer once appeared in a commercial for the drug — and made it easier to treat.

    Viagra originally developed for

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  5. Mar 27, 2013. Wednesday marks the 15th anniversary of Viagra's FDA approval in the. But how did a drug that was originally tested for the treatment of heart.

    • Viagra The little blue pill that could - CNN -.
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    Viagra is one of the best-known drugs of all time. Nearly every adult in America has heard of the drug and can tell you what it does. In the years since it was. Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile. Pfizer originally discovered the medication in 1989 while looking for a treatment for heart related chest pain. It was approved for medical use in the. From Velcro to Viagra 10 products that were invented by accident. Clinical trials at the pharmaceutical company Pfizer had originally studied Viagra's use as a.

     
  6. SergjoWM New Member

    Daniel Medforth, 36, of Withernsea, East Yorks, had an erection lasting longer than four hours. Medforth, a plasterer by trade and a married father of two, told U. tabloid The Sun that he took 35 doses of Viagra in an hour after drinking with his friends for two days.“My mate brought them downstairs, I just said I’d take one for a laugh and one led to two to three, et cetera,” Medforth told The Daily Beast. But after pill number 35, laughter gave way to concern. After his vision turned green—a Viagra side effect known as cyanopsia—and he experienced what he described to The Sun as “a massive erection that would not go away,” Medforth went home to his wife, who promptly redirected him to the hospital where he belonged. And there he stayed there for the next 36 hours—one hour for every year of his life that he almost threw away. He told The Daily Beast that his wife was “a little mad” at him, which, one would hope, is an understatement. He told The Sun, “It wasn’t a permanent erection but every time I brushed against something for five days it sprang into life—and it was no use to me.”How strange that his wife was not in the mood for sex after Medforth nearly left her a widow and their children fatherless. After his discharge, Medforth was put on bed rest but his penis refused to rest with him. But don’t worry, all is currently well at home.“Fortunately my wife has forgiven me and I realize I have been very, very lucky,” Medforth told The Sun. Two “very’s” might not be enough to capture the full extent of Medforth’s good fortune. Eleven babies die after Dutch women given Viagra-like drug in trial. Generic Viagra study Eleven babies died in stopped intrauterine. Виагра сеет смерть среди новорожденных
     
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