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    As practitioners of capitalism, Americans like to take for granted that competition keeps prices in check, which in turn keeps businesses on their toes while they deliver welcomed, price-trimming benefits to consumers. However, when viewing the market for medication that treats erectile dysfunction, or ED, that assumption simply and shockingly does not apply. And the steady, upward march of prices should be of growing concern to those with the condition (and anyone else -- e.g. purchasers of health insurance -- who indirectly subsidizes price increases in the prescription drug market). Publishing an illustration that delivers startling clarity about recent ED drug pricing, the deserves credit for cleanly laying out what has been taking place. Its graph, spanning 2013 to today, compares the list price of a single pill of Viagra to that of Cialis. And the lockstep laddering, for two products that are in direct competition with one another, is an attention grabber to say the least. Proposals are invited for the fifth annual Scientiae conference on disciplines of knowing in the early modern world (roughly 1400-1800). The major premise of this conference series is that knowledge during this period was inherently interdisciplinary, involving complex mixtures of theories, practices and objects, which had yet to be separated into their modern ‘scientific’ configurations. Although centred on attempts to understand and control the natural world, Scientiae addresses natural philosophy, natural history, and the scientiae mixtae within a wide range of related fields, including but not restricted to Biblical exegesis, medicine, artisan practice and theory, logic, humanism, alchemy, magic, witchcraft, demonology, divinatory practices, astronomy, astrology, music, antiquarianism, experimentation and commerce. Attention is also given to mapping intellectual geographies through the tools of the digital humanities. Please contact the conference convenor, Jo Hedesan, with any queries related to registration. A conference poster with registration details for Scientiae 2016 is now available to download. The final programme for Scientiae 2016 is now available to download. A downloadable catalogue of abstracts will be made available in due course.

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    Tadalafil is an orally administered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. Tadalafil's distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the "weekend pill." This longer half-life also is the basis of current investigation for tadalafil's use in pulmonary arterial hypertension as a once-daily therapy. The FDA is going to study a potential link between melanoma skin cancer and erectile dysfunction (ED) drugs such as Viagra, Cialis, and Levitra, according to information set forth in this document “January – March 2016: Potential Signals of Serious Risks/New Safety Information Identified from the FDA Adverse Event Reporting System (FAERS)”. In relevant part, the document listed these drugs which have been associated with melanoma as a serious side effect. PDE-5 inhibitors: Adcirca (tadalafil; Eli Lilly and Company): tablets Cialis (tadalafil; Eli Lilly and Company): tablets Levitra (vardenafil hydrochloride; Glaxo Smith Kline): orally disintegrating tablets Revatio (sildenafil citrate; Pfizer): tablets, oral suspension, and injection Staxyn (vardenafil hydrochloride; Glaxo Smith Kline): orally disintegrating tablets Stendra (avanafil; Vivus and Auxilium Pharmaceuticals): tablets Viagra (sildenafil citrate; Pfizer): tablets On the legal front, a growing number of Viagra – melanoma lawsuits have been filed against the drug company Pfizer. The federal court cases were consolidated in April 2016 before U. District Judge Richard Seeborg in the Northern District of California. Those Viagra cases are now part of a multidistrict litigation which often goes the short name “Viagra federal court MDL 2691”. As regards the general nature of these Viagra – melanoma lawsuits, many of the filed Complaints include allegations along these lines: We will continue to monitor both the legal and medical aspects developments concerning Viagra, Cialis, Levitra, and similar drugs being linked to melanoma skin cancer.

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    Antimicrobial stewardship has become a very important practice in optimal patient care. We want to try to limit as much unnecessary antibiotic exposure as possible, while providing optimal treatment. Treating acute otitis media (AOM) may seem simple enough. High dose amoxicillin 80-90 mg/ kg per day in 2 divided doses is the recommended medication for treatment of an initial episode of AOM. With antimicrobial stewardship practices, not only do we want to narrow antimicrobial therapy to specific organisms, but also provide appropriate duration of treatment. The duration for treating AOM in children is unclear. The idea of shorter therapy leading to less antimicrobial resistance is very true, but in AOM it may be leading to treatment failure causing additional exposure to antibiotics. Acute Otitis Media How Long Should You Treat? - Pharmacy Times Amoxicillin Tablets amoxicillin dose, indications, adverse effects. Otitis Media, Acute Clinical Pathway - chop.edu
     
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