Taking glimepiride with metformin

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  1. Lighter New Member

    Taking glimepiride with metformin


    Glimepiride, sold under the trade name Amaryl among others, is medium-to-long-acting sulfonylurea antidiabetic medication. It is sometimes classified as either the first third-generation sulfonylurea, Glimepiride is indicated to treat type 2 diabetes mellitus; its mode of action is to increase insulin secretion by the pancreas. However it requires adequate insulin synthesis as prerequisite to treat appropriately. It is not used for type 1 diabetes because in type 1 diabetes the pancreas is not able to produce insulin. Its use is contraindicated in patients with hypersensitivity to glimepiride or other sulfonylureas. Side effects from taking glimepiride include gastrointestinal tract (GI) disturbances, occasional allergic reactions, and rarely blood production disorders including thrombocytopenia, leukopenia, and hemolytic anemia. In the initial weeks of treatment, the risk of hypoglycemia may be increased. Alcohol consumption and exposure to sunlight should be restricted because they can worsen side effects. Glimepiride is an oral diabetes medicine that helps control blood sugar levels. Glimepiride is used together with diet and exercise to treat type 2 diabetes. Insulin or other diabetes medicines are sometimes used in combination with glimepiride if needed. Glimepiride may also be used for purposes not listed in this medication guide. You should not use glimepiride if you are allergic to it, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). To make sure glimepiride is safe for you, tell your doctor if you have: It is not known whether glimepiride will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery.

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    While taking glimepiride, you should tell your doctor if you Are pregnant, plan to become pregnant, or are breastfeeding. Combined use of glimepiride and metformin may increase the potential. Therefore be considered. The highest recommended dose per day should be 8 mg of glimepiride and 2000 mg Of metformin. Daily doses Of glimepiride Of more than 6 mg are. After this happened a couple of times I quit taking the Metformin. About a year later I was then diagnosed with T2 and am now on Glimepiride and have since began.

    Also known as: Amaryl The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. "I just started glimeperide 2mg 3 days ago so far no effects just hungry... I was on metformin 500mg at first it gave me real bad side effects diarrhea urinating all the time and losing 2lbs a day. Glimepiride seems to work better for me.""I was put on Glimepiride because I could no longer afford my other medication. I was on it four months, gained ten pounds in seven days, and my A1c jumped way up. Befroe this I was reaching my next goal weight..two pounds away..this sudden gain was devastating. Sodium–glucose cotransporter 2 (SGLT2) inhibitors improve glycaemia in patients with type 2 diabetes by enhancing urinary glucose excretion. We compared the efficacy and safety of canagliflozin, an SGLT2 inhibitor, with glimepiride in patients with type 2 diabetes inadequately controlled with metformin. We undertook this 52 week, randomised, double-blind, active-controlled, phase 3 non-inferiority trial at 157 centres in 19 countries between Aug 28, 2009, and Dec 21, 2011. Patients aged 18–80 years with type 2 diabetes and glycated haemoglobin A) of 7·0–9·5% on stable metformin were randomly assigned (1:1:1) by computer-generated random sequence via an interactive voice or web response system to receive canagliflozin 100 mg or 300 mg, or glimepiride (up-titrated to 6 mg or 8 mg per day) orally once daily. Patients, study investigators, and local sponsor personnel were masked to treatment. The primary endpoint was change in Hb A from baseline to week 52, with a non-inferiority margin of 0·3% for the comparison of each canagliflozin dose with glimepiride. If non-inferiority was shown, we assessed superiority on the basis of an upper bound of the 95% CI for the difference of each canagliflozin dose versus glimepiride of less than 0·0%.

    Taking glimepiride with metformin

    Glimepiride - Wikipedia, Amaryl® M S. R. Glimepiride & Metformin HCI

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  7. Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin CANTATA-SU 52 week results from a.

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    The present study showed that glimepiride/metformin fixed-dose. pill can improve patient compliance compared with taking multiple pills, and. One of the most common and beneficial T2DM drugs may contribute to neuropathy and vitamin deficiency The link between metformin and vitamin B12 lowering is. Glimepiride 4 mg or placebo was added in randomised order for three months with a washout period of 6 weeks. All insulin regimens were allowed. Insulin.

     
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